abstract：BACKGROUND:Although various studies have demonstrated efficacy of DNA-recombinant anti-hepatitis B vaccines, their effectiveness in health care settings has not been researched adequately. This gap is particularly visible for blood donors, a group of significant importance in the reduction of transfusion-transmitted he...

journal_title：BMC infectious diseases

authors： Kupek E,de Souza DE,Petry A

更新日期：2007-11-06 00:00:00

abstract：BACKGROUND:Polysaccharide pneumococcal vaccine is recommended for use in HIV-infected adults in Brazil but there is uncertainty about its effectiveness in this patient population. The main objective of this study was to assess the effectiveness of the 23-valent polysaccharide pneumococcal vaccine against invasive pneum...

journal_title：BMC infectious diseases

authors： Veras MA,Enanoria WT,Castilho EA,Reingold AL

更新日期：2007-10-23 00:00:00

abstract：BACKGROUND:Eight genotypes of Hepatitis B virus designated A-H, have been known but in Pakistan, no such data is available on the prevalent HBV genotypes. Therefore, the subject study was conducted to determine HBV genotypes in the indigenous Pakistani population. METHODS:A total of 690 individuals were enrolled for H...

journal_title：BMC infectious diseases

authors： Alam MM,Zaidi SZ,Malik SA,Shaukat S,Naeem A,Sharif S,Angez M,Butt JA

更新日期：2007-10-08 00:00:00

abstract：BACKGROUND:Emerging molecular, animal model and epidemiologic evidence suggests that Shiga-toxigenic Escherichia coli O157:H7 (STEC O157) isolates vary in their capacity to cause human infection and disease. The translocated intimin receptor (tir) and intimin (eae) are virulence factors and bacterial receptor-ligand pr...

journal_title：BMC infectious diseases

authors： Bono JL,Keen JE,Clawson ML,Durso LM,Heaton MP,Laegreid WW

更新日期：2007-08-24 00:00:00

abstract：BACKGROUND:NOD2, an intracellular pathogen recognition sensor, modulates innate defences to muropeptides derived from various bacterial species, including Mycobacterium tuberculosis (MTB). Experimentally, NOD2 attenuates two key putative mycobactericidal mechanisms. TNF-alpha synthesis is markedly reduced in MTB-antige...

journal_title：BMC infectious diseases

authors： Lala S,Dheda K,Chang JS,Huggett JF,Kim LU,Johnson MA,Rook GA,Keshav S,Zumla A

更新日期：2007-08-16 00:00:00

abstract：BACKGROUND:In Finland, the annual number of MRSA notifications to the National Infectious Disease Register (NIDR) has constantly increased since 1995, and molecular typing has revealed numerous outbreak isolates of MRSA. We analyzed the data on MRSA notifications of the NIDR, and MRSA isolates were identified mainly by...

journal_title：BMC infectious diseases

authors： Kerttula AM,Lyytikäinen O,Kardén-Lilja M,Ibrahem S,Salmenlinna S,Virolainen A,Vuopio-Varkila J

更新日期：2007-08-14 00:00:00

abstract：BACKGROUND:Clostridium difficile-associated disease (CDAD) is a serious nosocomial infection, however few studies have assessed CDAD outcome in the intensive care unit (ICU). We evaluated the epidemiology, clinical course and outcome of hospital-acquired CDAD in the critical care setting. METHODS:We performed a histor...

journal_title：BMC infectious diseases

authors： Marra AR,Edmond MB,Wenzel RP,Bearman GM

更新日期：2007-05-21 00:00:00

abstract：BACKGROUND:Acute respiratory tract infections (ARTI) are an important public health problem. Improved identification of risk factors might enable targeted intervention. Therefore we carried out a case-control study with the aim of identifying environmental risk factors for ARTI consultations in the Dutch general popula...

journal_title：BMC infectious diseases

authors： van Gageldonk-Lafeber AB,van der Sande MA,Heijnen ML,Peeters MF,Bartelds AI,Wilbrink B

更新日期：2007-04-27 00:00:00

abstract：BACKGROUND:This report discusses a case of unsuccessful treatment with recombinant factor VIIa (rFVIIa) in off-label use. The need for international guidelines concerning the off-label use of rFVIIa is outlined as well as the need for methods to control the efficacy of rFVIIa objectively. CASE PRESENTATION:54 year old...

journal_title：BMC infectious diseases

authors： Conen A,Weisser M,Tsakiris DA,Siegemund M

更新日期：2007-04-26 00:00:00

abstract：BACKGROUND:Fungal infections are diagnosed increasingly often in patients affected by hematological diseases and their mortality has remained high. The recent development of new antifungal drugs gives the clinician the possibility to assess the combination of antifungal drugs with in-vitro or in animal-model synergisti...

journal_title：BMC infectious diseases

authors： Cesaro S,Giacchino M,Locatelli F,Spiller M,Buldini B,Castellini C,Caselli D,Giraldi E,Tucci F,Tridello G,Rossi MR,Castagnola E

更新日期：2007-04-18 00:00:00

abstract：BACKGROUND:Vancomycin resistant enterococcus (VRE) is a major cause of nosocomial infections in the United States and may be associated with greater morbidity, mortality, and healthcare costs than vancomycin-susceptible enterococcus. Current guidelines for the control of VRE include prudent use of vancomycin. While van...

journal_title：BMC infectious diseases

authors： de Bruin MA,Riley LW

更新日期：2007-04-10 00:00:00

abstract：BACKGROUND:Nitric oxide (NO*) plays a pivotal role as a leishmanicidal agent in mouse macrophages. NO* resistant Escherichia coli and Mycobacterium tuberculosis have been associated with a severe outcome of these diseases. METHODS:In this study we evaluated the in vitro toxicity of nitric oxide for the promastigote st...

journal_title：BMC infectious diseases

authors： Giudice A,Camada I,Leopoldo PT,Pereira JM,Riley LW,Wilson ME,Ho JL,de Jesus AR,Carvalho EM,Almeida RP

更新日期：2007-02-22 00:00:00

abstract：BACKGROUND:There are few reports in the literature of invasive infection caused by Brevundimonas vesicularis in patients without immunosuppression or other predisposing factors. The choice of antimicrobial therapy for bacteremia caused by the pathogen requires more case experience to be determined. CASE PRESENTATION:T...

journal_title：BMC infectious diseases

authors： Yang ML,Chen YH,Chen TC,Lin WR,Lin CY,Lu PL

更新日期：2006-12-29 00:00:00

abstract：BACKGROUND:African malaria vectors bite predominantly indoors at night so sleeping under an Insecticide-Treated Net (ITN) can greatly reduce malaria risk. Behavioural adaptation by mosquitoes to increasing ITN coverage could allow vector mosquitoes to bite outside of peak sleeping hours and undermine efficacy of this k...

journal_title：BMC infectious diseases

authors： Killeen GF,Kihonda J,Lyimo E,Oketch FR,Kotas ME,Mathenge E,Schellenberg JA,Lengeler C,Smith TA,Drakeley CJ

更新日期：2006-11-10 00:00:00

abstract：BACKGROUND:Respiratory syncytial virus (RSV) is an important pathogen that can cause severe illness in infants and young children. In this study, we assessed whether data on RSV collected by the European Influenza Surveillance Scheme (EISS) could be used to build an RSV surveillance system in Europe. METHODS:Influenza...

journal_title：BMC infectious diseases

authors： Meerhoff TJ,Fleming D,Smith A,Mosnier A,van Gageldonk-Lafeber AB,Paget WJ,EISS RSV Task Group.

更新日期：2006-08-09 00:00:00

abstract：BACKGROUND:Lemierre's syndrome presents a classic clinical picture, the pathophysiology of which remains obscure. Attempts have been made to trace genetic predispositions that modify the host detection of pathogen or the resultant systemic reaction. CASE PRESENTATION:A 17-year old female, with no previous medical hist...

journal_title：BMC infectious diseases

authors： Constantin JM,Mira JP,Guerin R,Cayot-Constantin S,Lesens O,Gourdon F,Romaszko JP,Linval P,Laurichesse H,Bazin JE

更新日期：2006-07-17 00:00:00

abstract：BACKGROUND:Injecting drug use is a key risk factor, for several infections of public health importance, especially hepatitis B (HBV) and hepatitis C (HCV). In England and Wales, where less than 1% of the population are likely to be injecting drug users (IDUs), approximately 38% of laboratory reports of HBV, and 95% of ...

journal_title：BMC infectious diseases

authors： Sutton AJ,Gay NJ,Edmunds WJ,Hope VD,Gill ON,Hickman M

更新日期：2006-06-08 00:00:00

abstract：BACKGROUND:Helicobacter cinaedi is a rare pathogen in humans, occurring mostly in immuno-compromised patients, with a high potential for recurrence. We describe a case of a patient with lymphoma hospitalized for chemotherapy. CASE PRESENTATION:At admission, the patient presented with an indolent and non-prurigenic mac...

journal_title：BMC infectious diseases

authors： Uçkay I,Garbino J,Dietrich PY,Ninet B,Rohner P,Jacomo V

更新日期：2006-05-23 00:00:00

abstract：BACKGROUND:Low serum selenium has been associated with lower CD4 counts and greater mortality among HIV-1-seropositive individuals, but most studies have not controlled for serum albumin and the presence of an acute phase response. METHODS:A cross-sectional study was conducted to evaluate relationships between serum s...

journal_title：BMC infectious diseases

authors： Drain PK,Baeten JM,Overbaugh J,Wener MH,Bankson DD,Lavreys L,Mandaliya K,Ndinya-Achola JO,McClelland RS

更新日期：2006-05-19 00:00:00

abstract：BACKGROUND:Adherence of Streptococcus pneumoniae bacteria to lung cells is a first step in the progression from asymptomatic carriage to pneumonia. Adherence abilities vary widely among S. pneumoniae patient isolates. In this study, the binding properties of S. pneumoniae isolates and the effects of binding on activati...

journal_title：BMC infectious diseases

authors： Robson RL,Reed NA,Horvat RT

更新日期：2006-04-11 00:00:00

abstract：BACKGROUND:The seasonality, clinical and radiographic features and outcome of aseptic meningitis have been described for regional outbreaks but data from a wider geographic area is necessary to delineate the epidemiology of this condition. METHODS:A retrospective chart review was completed of children presenting with ...

journal_title：BMC infectious diseases

authors： Lee BE,Chawla R,Langley JM,Forgie SE,Al-Hosni M,Baerg K,Husain E,Strong J,Robinson JL,Allen U,Law BJ,Dobson S,Davies HD

更新日期：2006-04-10 00:00:00

abstract：BACKGROUND:Patients with HIV infection are at risk of co-infection with HBV, as the routes of transmission are shared and thus immunization with HBV vaccine could be protective in them. The aim of the present study was to assess the efficacy of recombinant vaccine in treatment-naive HIV positive patients and healthy co...

journal_title：BMC infectious diseases

authors： Pasricha N,Datta U,Chawla Y,Singh S,Arora SK,Sud A,Minz RW,Saikia B,Singh H,James I,Sehgal S

更新日期：2006-03-30 00:00:00

abstract：BACKGROUND:The role of Diabetes mellitus (DM) in the etiology and in the antimicrobial resistance of uropathogens in patients with urinary tract infection has not been well clarified. For this reason we have evaluated the spectrum of uropathogens and the profile of antibiotic resistance in both diabetic and non diabeti...

journal_title：BMC infectious diseases

authors： Bonadio M,Costarelli S,Morelli G,Tartaglia T

更新日期：2006-03-17 00:00:00

abstract：BACKGROUND:In Australia two acellular Bordetella pertussis vaccines have replaced the use of a whole cell vaccine. Both of the licensed acellular vaccines contain the following three components; pertussis toxoid, pertussis filamentous haemagglutinin and the 69 kDa pertactin adhesin. One vaccine also contains pertussis ...

journal_title：BMC infectious diseases

authors： Byrne S,Slack AT

更新日期：2006-03-16 00:00:00

abstract：BACKGROUND:Bloodstream infection (BSI) due to Pseudomonas aeruginosa (Pa) has relevant clinical impact especially in relation to drug resistance determinants. The PER-1 extended-spectrum beta-lactamase (ESBL) is a common enzyme conferring high-level resistance to anti-pseudomonal cephalosporins. Risk factors and treatm...

journal_title：BMC infectious diseases

authors： Endimiani A,Luzzaro F,Pini B,Amicosante G,Rossolini GM,Toniolo AQ

更新日期：2006-03-16 00:00:00

abstract：BACKGROUND:Typhoid fever is a systemic infection caused by the bacterium Salmonella enterica subspecies enterica serotype typhi, which is acquired by ingestion of contaminated food and water. Each year the disease affects at least 16 million persons world-wide, most of whom reside in the developing countries of Southea...

journal_title：BMC infectious diseases

authors： Colomba C,Saporito L,Infurnari L,Tumminia S,Titone L

更新日期：2006-02-27 00:00:00

abstract：BACKGROUND:Syndromic management of STIs has been advocated as simplified and cheap approach. Youth have been reported to be at increased risk of acquiring STIs which can facilitate HIV transmission. We have investigated the relationship between the syndromic management and specific aetiology diagnosis and its relations...

journal_title：BMC infectious diseases

authors： Chalamilla G,Mbwana J,Mhalu F,Mmari E,Majigo M,Swai A,Urassa W,Sandstrom E

更新日期：2006-02-10 00:00:00

abstract：BACKGROUND:A reliable prediction of the causative agent of community-acquired pneumonia (CAP) is not possible based on clinical features. Our aim was to test, whether the measurement of the expression of complement receptors or Fcgamma receptors on neutrophils and monocytes would be a useful preliminary test to differe...

journal_title：BMC infectious diseases

authors： Hohenthal U,Nuutila J,Lilius EM,Laitinen I,Nikoskelainen J,Kotilainen P

更新日期：2006-01-24 00:00:00

abstract：BACKGROUND:Data on sexually transmitted infections (STIs) in Saudi Arabia (SA) and other Islamic countries are limited. This study describes the results of a five-year surveillance for STIs in SA. METHODS:This is a case series descriptive study of all confirmed STIs diagnosed in SA from January, 1995 through December,...

journal_title：BMC infectious diseases

authors： Madani TA

更新日期：2006-01-10 00:00:00

abstract：BACKGROUND:The incidence of tuberculous pericarditis has increased in Africa as a result of the human immunodeficiency virus (HIV) epidemic. However, the effect of HIV co-infection on clinical features and prognosis in tuberculous pericarditis is not well characterised. We have used baseline data of the Investigation o...

journal_title：BMC infectious diseases

authors： Mayosi BM,Wiysonge CS,Ntsekhe M,Volmink JA,Gumedze F,Maartens G,Aje A,Thomas BM,Thomas KM,Awotedu AA,Thembela B,Mntla P,Maritz F,Blackett KN,Nkouonlack DC,Burch VC,Rebe K,Parish A,Sliwa K,Vezi BZ,Alam N,Brown BG

更新日期：2006-01-06 00:00:00

abstract：BACKGROUND:The objective of this study was to establish 1) the performance of chest X-ray (CXR) in all suspects of tuberculosis (TB), as well as smear-negative TB suspects and 2) to compare the cost-effectiveness of the routine diagnostic pathway using Ziehl-Neelsen (ZN) sputum microscopy followed by CXR if case of neg...

journal_title：BMC infectious diseases

authors： van Cleeff MR,Kivihya-Ndugga LE,Meme H,Odhiambo JA,Klatser PR

更新日期：2005-12-12 00:00:00

abstract：BACKGROUND:Delayed diagnosis and treatment of tuberculosis (TB) results in severe disease and a higher mortality. It also leads to an increased period of infectivity in the community. The objective of this study was to determine the length of delays, and analyze the factors affecting the delay from onset of symptoms of...

journal_title：BMC infectious diseases

authors： Yimer S,Bjune G,Alene G

更新日期：2005-12-12 00:00:00

abstract：BACKGROUND:Chlamydia trachomatis is the most common sexually transmitted bacterial pathogen causing female genital tract infection throughout the world. Reinfection with the same serovar, as well as multiple infections with different serovars, occurs in humans. Using a murine model of female C. trachomatis genital trac...

journal_title：BMC infectious diseases

authors： Lyons JM,Morré SA,Airo-Brown LP,Peña AS,Ito JI

更新日期：2005-11-17 00:00:00

abstract：BACKGROUND:To determine the association of human papillomavirus infection (HPV) and transitional cell carcinoma (TCC). METHODS:Using polymerase chain reaction, fifty-nine bladder tissue specimens of patients with transitional cell carcinoma of bladder compared with 20 bladder samples of cases with non-neoplastic disor...

journal_title：BMC infectious diseases

authors： Barghi MR,Hajimohammadmehdiarbab A,Moghaddam SM,Kazemi B

更新日期：2005-11-08 00:00:00

abstract：BACKGROUND:Both cell-associated and cell-free HIV virions are present in semen and cervical secretions of HIV-infected individuals. Thus, topical microbicides may need to inactivate both cell-associated and cell-free HIV to prevent sexual transmission of HIV/AIDS. To determine if the mild acidity of the healthy vagina ...

journal_title：BMC infectious diseases

authors： Olmsted SS,Khanna KV,Ng EM,Whitten ST,Johnson ON 3rd,Markham RB,Cone RA,Moench TR

更新日期：2005-09-30 00:00:00

abstract：BACKGROUND:Leprosy still remains an important public health problem for many parts of the world. An association of gangrene with leprosy is a rare one & can have a number of causative mechanisms. We present a case with Leprosy & gangrene with positive anti phopholipid antibody titers. CASE PRESENTATION:A 50-year-old n...

journal_title：BMC infectious diseases

authors： Akerkar SM,Bichile LS

更新日期：2005-09-21 00:00:00

abstract：BACKGROUND:Mycoplasmas are present worldwide in a large number of animal hosts. Due to their small genome and parasitic lifestyle, Mycoplasma spp. require complex isolation media. Nevertheless, already over 100 different species have been identified and characterized and their number increases as more hosts are sampled...

journal_title：BMC infectious diseases

authors： Stakenborg T,Vicca J,Butaye P,Maes D,De Baere T,Verhelst R,Peeters J,de Kruif A,Haesebrouck F,Vaneechoutte M

更新日期：2005-06-14 00:00:00

abstract：BACKGROUND:Community-acquired pneumonia (CAP) remains a major cause of morbidity and mortality throughout the world. Telithromycin (a new ketolide) has shown good in vitro activity against the key causative pathogens of CAP, including S pneumoniae resistant to penicillin and/or macrolides. METHODS:The efficacy and saf...

journal_title：BMC infectious diseases

authors： Fogarty CM,Patel TC,Dunbar LM,Leroy BP

更新日期：2005-05-31 00:00:00

abstract：BACKGROUND:Bacterial vaginosis (BV) - a syndrome characterised by a shift in vaginal flora - appears to be particularly common in sub-Saharan Africa, but little is known of the pattern of vaginal flora associated with BV in Africa. We conducted a study aimed at determining the prevalence of BV and patterns of BV-associ...

journal_title：BMC infectious diseases

authors： Demba E,Morison L,van der Loeff MS,Awasana AA,Gooding E,Bailey R,Mayaud P,West B

更新日期：2005-03-09 00:00:00

abstract：BACKGROUND:Prion diseases are caused by the accumulation of an aberrantly folded isoform of the prion protein, designated PrPSc. In a cell-based assay, quinacrine inhibits the conversion of normal host prion protein (PrPC) to PrPSc at a half-maximal concentration of 300 nM. While these data suggest that quinacrine may ...

journal_title：BMC infectious diseases

authors： Yung L,Huang Y,Lessard P,Legname G,Lin ET,Baldwin M,Prusiner SB,Ryou C,Guglielmo BJ

更新日期：2004-11-29 00:00:00